2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione Chemical Properties

Boiling point:

521.5±45.0 °C(Predicted)

Density 

1.570±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO: 83.33 mg/mL (301.68 mM)

pka

10.65±0.40(Predicted)

form 

Solid

color 

Off-white to gray

InChI

InChI=1S/C13H9FN2O4/c14-6-1-2-7-8(5-6)13(20)16(12(7)19)9-3-4-10(17)15-11(9)18/h1-2,5,9H,3-4H2,(H,15,17,18)

InChIKey

MPQLCQKBYRSPNA-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C=C(F)C=C2)C(=O)N1C1CCC(=O)NC1=O

2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione Usage And Synthesis

Description

2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione is a thalidomide analog that can be useful in PROTAC research.

Uses

Thalidomide 5'- fluoro (2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione) is a derivative of Thalidomide, commonly used as a precursor to PROTAC® Degraders that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a fluoro functional handle at a position known not to significantly affect binding to cereblon, ready for conjugation to a linker/target protein ligand.

storage

Store at +4°C