2-AMINO-9H-PYRIDO[2,3-B]INDOLE Chemical Properties

Melting point:

194-196

Boiling point:

306.89°C (rough estimate)

Density 

1.2078 (rough estimate)

refractive index 

1.6500 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

Methanol (Slightly)

pka

14.87±0.40(Predicted)

form 

Solid

color 

Beige to Light Orange

InChI

InChI=1S/C11H9N3/c12-10-6-5-8-7-3-1-2-4-9(7)13-11(8)14-10/h1-6H,(H3,12,13,14)

InChIKey

FJTNLJLPLJDTRM-UHFFFAOYSA-N

SMILES

N1C2=C(C=CC=C2)C2=CC=C(N)N=C12

CAS DataBase Reference

26148-68-5(CAS DataBase Reference)

IARC

2B (Vol. 40, Sup 7) 1987

EPA Substance Registry System

2-Amino-9H-pyrido[2,3-b]indole (26148-68-5)

Safety Information

Hazard Codes 

Xi

RIDADR 

2811

Hazard Note 

Irritant/Mutagen

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2933998090

Hazardous Substances Data

26148-68-5(Hazardous Substances Data)

2-AMINO-9H-PYRIDO[2,3-B]INDOLE Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

A pyrolysate that exhibited mutagenic activity toward Salmonella typhimurium TA98 and TA100 from the pyrolytic products of soybean globulin. 2-Amino-9H-pyrido[2,3-b]indole (AαC) and 2-amino-3-methyl-9 H-pyrido[2,3-b]indole (MeAαC) are two mutagenic and carcinogenic heterocyclic amines formed during ordinary cooking.

Definition

ChEBI: 2-Amino-9H-pyrido[2,3-b]indole is a pyridoindole.

Biological Activity

AαC (2-Amino-9H-pyrido[2-3-b]indole) is a potential human carcinogen, which is generated by the combustion of tobacco, or by pyrolysis of protein. AαC potentially contributes to liver or digestive tract cancers. Inside body AαC is metabolized to intermediates (possibly short-lived nitrenium ion of AαC) th at react with DNA.

Safety Profile

Suspected carcinogen with experimental carcinogenic data. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.

2-AMINO-9H-PYRIDO[2,3-B]INDOLE(26148-68-5)Related Product Information

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• 2-Amino-3-ethyl-9H-pyrido(2,3-b)indole