[1,1'-Biphenyl]-2-carboxamide, N-[1,2,3,4-tetrahydro-2-(1H-imidazol-2-ylmethyl)-6-isoquinolinyl]-4'-(trifluoromethyl)- Chemical Properties

Boiling point:

594.3±50.0 °C(Predicted)

Density 

1.342±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

13.21±0.20(Predicted)

[1,1'-Biphenyl]-2-carboxamide, N-[1,2,3,4-tetrahydro-2-(1H-imidazol-2-ylmethyl)-6-isoquinolinyl]-4'-(trifluoromethyl)- Usage And Synthesis

Uses

CP-319340 free base is a microsomal triglyceride transfer protein (MTP) inhibitor.

References

[1] Sugi, Kiyoshi, et al. Process for producing 4-(2-methylphenyl)benzotrifluoride. EP1700837A1.
[2] Ye, Jin, et al. Treating hepatitis C virus infection. US20080175864A1.
[3] Hussain MM, et al. Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res. 2003 Jan;44(1):22-32. DOI:10.1194/jlr.r200014-jlr200