CB-1158 Chemical Properties

Boiling point:

596.9±60.0 °C(Predicted)

Density 

1.327±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO: soluble

form 

A solid

pka

2.25±0.44(Predicted)

CB-1158 Usage And Synthesis

Uses

CB 1158 is a potent arginase inhibitor. CB-1158 has the potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role. CB-1158 may also have the ability to combine with other immuno-oncology therapies that target T-cell activation, such as CTLA-4 and PD-1 antibodies.