CWP232228
CWP232228 Basic information
- Product Name:
- CWP232228
- Synonyms:
-
- CWP232228
- CWP232228?sodium
- CWP232228 disodium
- Beta catenin,Wnt,Breast,β-catenin,Inhibitor,CWP232228,CWP 232228,cells,signaling,stem,Cancer,inhibit,liver,CWP-232228
- Sodium 4-(((6S,9aS)-2-allyl-1-(benzylcarbamoyl)-8-((2-methyl-2H-indazol-7-yl)methyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl phosphate
- CAS:
- 1144044-02-9
- MF:
- C33H37N7NaO7P
- MW:
- 697.66
- Mol File:
- 1144044-02-9.mol
CWP232228 Chemical Properties
- form
- Solid
- color
- White to off-white
- InChIKey
- RCZZPLXBWBXLAA-RYRAPZCFNA-N
- SMILES
- C(N1N(CC(=O)N2[C@H](C(=O)N(CC3=CC=CC4=CN(C)N=C34)C[C@]12[H])CC1C=CC(OP(O)(O)=O)=CC=1)CC=C)(=O)NCC1C=CC=CC=1.[NaH] |&1:7,23,r|
CWP232228 Usage And Synthesis
Uses
CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs)[1].
in vivo
CWP232228 (100 mg/kg, administered i.p.; daily; 21days for mice bearing 4T1 cell tumors; 60 days for mice bearing MDA-MB-435 cell tumors) results in a significant reduction in tumor volume[1].
| Animal Model: | 7-week-old female Balb/c and NOD/SCID mice bearing 4T1 or MDA-MB-435 cell tumors[1] |
| Dosage: | 100 mg/kg |
| Administration: | Administered i.p.; daily; 21days for mice bearing 4T1 cell tumors, 60 days for mice bearing MDA-MB-435 cell tumors |
| Result: | Treatment resulted in a significant reduction in tumor volume. |
References
[1] Jang GB, et al. Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells. Cancer Res. 2015 Apr 15;75(8):1691-702. DOI:10.1158/0008-5472.CAN-14-2041
[2] Kim JY, et al. Oncotarget. 2016 Apr 12;7(15):20395-409. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment. DOI:10.18632/oncotarget.7954
CWP232228Supplier
- Tel
- 13611719524
- 2674347328@qq.com
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 021-52996696，15000506266 15000506266
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
- Tel
- 021-61350663 15502154572
- 1639466865@qq.com