JAK2 JH2 Tracer
JAK2 JH2 Tracer Basic information
- Product Name:
- JAK2 JH2 Tracer
- Synonyms:
-
- JAK2 JH2 Tracer
- Thiourea, N-[[4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]phenyl]methyl]-N'-(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)-N-methyl-
- CAS:
- 2101955-00-2
- MF:
- C38H27F2N7O6S
- MW:
- 747.73
- Mol File:
- 2101955-00-2.mol
JAK2 JH2 Tracer Chemical Properties
- Boiling point:
- 985.4±75.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- pka
- 9.33±0.20(Predicted)
- form
- Solid
- color
- Light brown to brown
JAK2 JH2 Tracer Usage And Synthesis
Uses
JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM[1][2].
in vivo
The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies[2]. Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases[2].
References
[1] Newton AS, et al. JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Med Chem Lett. 2017 May 17;8(6):614-617. DOI:10.1021/acsmedchemlett.7b00154
[2] Ihle JN, Gilliland DG. Jak2: normal function and role in hematopoietic disorders. Curr Opin Genet Dev. 2007 Feb;17(1):8-14. DOI:10.1016/j.gde.2006.12.009
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