NGP 555
NGP 555 Basic information
- Product Name:
- NGP 555
- Synonyms:
-
- NGP 555
- N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine
- 2-Thiazolamine, N-(5-ethyl-2,4-dimethylphenyl)-4-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]-
- NGP 555,Inhibitor,γ-secretase,inhibit,NGP555,Gamma secretase,NGP-555
- NGP555, 10 mM in DMSO
- CAS:
- 1304630-27-0
- MF:
- C23H23FN4S
- MW:
- 406.52
- Mol File:
- 1304630-27-0.mol
NGP 555 Chemical Properties
- Boiling point:
- 574.9±60.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 5.16±0.61(Predicted)
- color
- White to off-white
NGP 555 Usage And Synthesis
Uses
NGP555, is a γ-secretase modulator. It significantly lowers Aβ42 in cell cultures. it also has shown good oral bioavailability and is brain-penetrant.
in vivo
NGP555 significantly lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post dose, panel B shows that reduction of Aβ cerebrospinal fluid (CSF) levels is significant at 3.75 mg/kg of NGP555 and above, and panel C shows an increase in Aβ38 levels at 15 mg/kg of NGP555 and above. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above (panel D). NGP555-treated Tg mice show a significant protection from decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 also shows good oral bioavailability and is brain-penetrant with a brain:plasma ratio of ~0.93 in mice[1].
NGP 555Supplier
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