AFG210 Chemical Properties

Boiling point:

396.7±42.0 °C(Predicted)

Density 

1.397±0.06 g/cm3(Predicted)

pka

13.44±0.70(Predicted)

AFG210 Usage And Synthesis

Description

AFG210 is a novel first-generation “type II” FLT3 inhibitor.

Uses

AFG210 is a potent multi-target kinase inhibitor that primarily inhibits Abl kinase (IC50=330 nM), and also has inhibitory effects on other kinases such as B-Raf, C-Raf, FGFR-1, RET and VEGF receptors. AFG210 can be used to study chronic myeloid leukemia and other diseases with abnormal activation of Abl kinase[1].

References

[1] AC Backes, et al. Small-molecule inhibitors binding to protein kinase. Part II: the novel pharmacophore approach of type II and type III inhibition. Expert opinion on drug discovery, 3(12), 1427-1449. DOI:10.1517/17460440802580106