Benzoic acid, 4-[3-[(4-methylphenyl)sulfonyl]-2-[[(4-methylphenyl)sulfonyl]methyl]-1-oxopropyl]- Chemical Properties

Boiling point:

803.7±65.0 °C(Predicted)

Density 

1.346±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

Solid

pka

3.70±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2918300090

Benzoic acid, 4-[3-[(4-methylphenyl)sulfonyl]-2-[[(4-methylphenyl)sulfonyl]methyl]-1-oxopropyl]- Usage And Synthesis

Uses

4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to “staple” two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.