2-(2-(2-azidoethoxy)ethoxy)ethyl methanesulfonate
2-(2-(2-azidoethoxy)ethoxy)ethyl methanesulfonate Basic information
- Product Name:
- 2-(2-(2-azidoethoxy)ethoxy)ethyl methanesulfonate
- Synonyms:
-
- 2-(2-(2-azidoethoxy)ethoxy)ethyl methanesulfonate
- Azido-PEG3-MS , Azido-PEG3-MS
- CAS:
- 176520-24-4
- MF:
- C7H15N3O5S
- MW:
- 253.27
- Mol File:
- 176520-24-4.mol
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2-(2-(2-azidoethoxy)ethoxy)ethyl methanesulfonate Usage And Synthesis
Uses
Azido-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-MS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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