Active-Mono-Sulfone-PEG8-acid Chemical Properties

Boiling point:

903.1±65.0 °C(Predicted)

Density 

1.210±0.06 g/cm3(Predicted)

pka

4.28±0.10(Predicted)

Active-Mono-Sulfone-PEG8-acid Usage And Synthesis

Description

Active-Mono-Sulfone-PEG8-acid is a PEG linker with a sulfone and acid end group. The sulfone group can be conjugated with thiol groups of proteins. The terminal carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to from stable amide bonds. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media.

Uses

Active-mono-sulfone-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005