ethyl rosmarinate
ethyl rosmarinate Basic information
- Product Name:
- ethyl rosmarinate
- Synonyms:
-
- ethyl rosmarinate
- Benzenepropanoic acid, α-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, ethyl ester, (αR)-
- ethyl rosmarinate, 10 mM in DMSO
- (R)-3-(3,4-Dihydroxyphenyl)-1-ethoxy-1-oxopropan-2-yl (E)-3-(3,4-dihydroxyphenyl)acrylate
- CAS:
- 174591-47-0
- MF:
- C20H20O8
- MW:
- 388.37
- Mol File:
- 174591-47-0.mol
ethyl rosmarinate Chemical Properties
- Boiling point:
- 658.7±55.0 °C(Predicted)
- Density
- 1.413±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 2mg/mL, clear
- form
- Solid
- pka
- 9.30±0.10(Predicted)
- color
- White to off-white
ethyl rosmarinate Usage And Synthesis
Uses
Ethyl rosmarinate is a phenolic compound that can be isolated from Lycopus lucidus. Ethyl rosmarinate has antioxidative activity. Ethyl rosmarinate inhibits lung inflammation[1][2].
Biological Activity
Ethyl rosmarinate is an anti-inflammatory and antioxidative compound present in Lycopus lucidus, Hyptis suaveolens and other medical plants th at potently inhibits LPS induced production of nitric oxide and prostaglandin E2 in alveolar macrophages. Ethyl rosmarinate induces relaxation in aortic rings via an endothelium-independent pathway.
References
[1] Woo ER, et al. Antioxidative constituents from Lycopus lucidus. Arch Pharm Res. 2004 Feb;27(2):173-6. DOI:10.1007/BF02980102
[2] Thammason H, et al. Ethyl rosmarinate inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in alveolar macrophages. Eur J Pharmacol. 2018 Apr 5;824:17-23. DOI:10.1016/j.ejphar.2018.01.042
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