E3 ligase Ligand-Linker Conjugates 10
E3 ligase Ligand-Linker Conjugates 10 Basic information
- Product Name:
- E3 ligase Ligand-Linker Conjugates 10
- Synonyms:
-
- E3 ligase Ligand-Linker Conjugates 10
- (S,R,S)-AHPC-PEG2-butyl chloride
- VH032-PEG2-C4-Cl
- VHL Ligand-Linker Conjugates 7
- L-Prolinamide, N-[2-[2-[(6-chlorohexyl)oxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
- (S,R,S)-AHPC-2-2-6-Cl
- (2S,4R)-1-((S)-2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-2-2-6-Cl, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CAS:
- 1835705-57-1
- MF:
- C32H47ClN4O6S
- MW:
- 651.26
- Mol File:
- 1835705-57-1.mol
E3 ligase Ligand-Linker Conjugates 10 Chemical Properties
- Boiling point:
- 870.2±65.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : ≥ 50 mg/mL (76.77 mM)
- pka
- 13.55±0.46(Predicted)
E3 ligase Ligand-Linker Conjugates 10 Usage And Synthesis
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG2-Butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
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