Fulvestrant (ICI 182780) S enantiomer
Fulvestrant (ICI 182780) S enantiomer Basic information
- Product Name:
- Fulvestrant (ICI 182780) S enantiomer
- Synonyms:
-
- Fulvestrant (ICI 182780) S enantiomer
- Fulvestrant S enantiomer
- Fulvestrant impurity 11/Fulvestrant S enantiomer
- ICI 182780 S enantiomer
- ZD 9238 S enantiomer
- ZM 182780 S enantiomer
- Estra-1,3,5(10)-triene-3,17-diol, 7-[9-[(S)-(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-, (7α,17β)-
- (1S,3aS,4R,9bS,11aS)-11a-methyl-4-[9-(4,4,5,5,5-p entafluoropentanesulfinyl)nonyl]-1H,2H,3H,3aH,3 bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phena nthrene-1,7-diol
- CAS:
- 1316849-17-8
- MF:
- C32H47F5O3S
- MW:
- 606.78
- Mol File:
- 1316849-17-8.mol
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Fulvestrant (ICI 182780) S enantiomer Chemical Properties
- Boiling point:
- 674.8±55.0 °C(Predicted)
- Density
- 1.201±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 10.27±0.70(Predicted)
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Fulvestrant (ICI 182780) S enantiomer Usage And Synthesis
Uses
Fulvestrant S enantiomer (ICI 182780 S enantiomer) is the S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM.
References
[1] Caprioglio D, et al. An alternative synthesis of the breast cancer drug fulvestrant (Faslodex?): catalyst control over C-C bond formation. Chem Commun (Camb). 2015;51(80):14866-14868. DOI:10.1039/c5cc05805h
[2] Wakeling AE, et al. A potent specific pure antiestrogen with clinical potential. Cancer Res. 1991;51(15):3867-3873. PMID:1855205
Fulvestrant (ICI 182780) S enantiomerSupplier
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
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