Basic information Safety Supplier Related

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER

Basic information Safety Supplier Related

15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER Basic information

Product Name:
15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER
Synonyms:
  • 15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER
  • 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester
  • 15(R)-Bimatoprost isopropyl ester
  • JGZRPRSJSQLFBO-DYZSFVSISA-N
  • 15-epi Bimatoprost isopropyl ester
  • 9ALPHA,11ALPHA,15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
  • BIMATOPROST ISOPROPYL ESTER/7-[(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3R)-3-HYDROXY-5-PHENYL-1-PENTEN-1-
  • Bimatoprost Isopropyl Ester/7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-Hydroxy-5-Phenyl-1-Penten-1-Yl]Cyclopentyl]-(5Z)-5-Heptenoic Acid 1-Methylethyl Ester
CAS:
130273-87-9
MF:
C26H38O5
MW:
430.58
Mol File:
130273-87-9.mol
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15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMF:30.0(Max Conc. mg/mL);69.67(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);69.67(Max Conc. mM)
PBS (pH 7.2):1.0(Max Conc. mg/mL);2.32(Max Conc. mM)
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15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER Usage And Synthesis

Description

15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.

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15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER(130273-87-9)Related Product Information