1,2,5,8-TETRAHYDROXYANTHRAQUINONE Chemical Properties

Melting point:

≥300 °C

Boiling point:

375.27°C (rough estimate)

Density 

1.4292 (rough estimate)

refractive index 

1.5230 (estimate)

storage temp. 

room temp

form 

powder

Colour Index 

58500

color 

red

Water Solubility 

2.586mg/L(25 ºC)

BRN 

1889617

CAS DataBase Reference

81-61-8(CAS DataBase Reference)

EPA Substance Registry System

9,10-Anthracenedione, 1,2,5,8-tetrahydroxy- (81-61-8)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

36/37/38-50-22

Safety Statements 

26-36-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

1,2,5,8-TETRAHYDROXYANTHRAQUINONE Usage And Synthesis

Uses

1,2,5,8-TETRAHYDROXYANTHRAQUINONE is Al salts dark red, cotton mordanted with Cr salts bluish-violet. No longer used as a dye, except occasionally in printing cotton.

Definition

ChEBI: A tetrahydroxyanthraquinone having the four hydroxy groups at the 1-, 2-, 5- and 8-positions.

Preparation

Quinalizarin. 1,2-Dihydroxyanthracene-9,10-dione or 1,4-Dihydroxyanthracene-9,10-dione with great excess fuming sulfuric acid oxidation and hydrolysis.

Biochem/physiol Actions

Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.

Properties and Applications

violet (chromium), dark red light purple (aluminum). Soluble in ethanol. In concentrated sulfuric acid for blue purple, dilution after dark red precipitation.

Purification Methods

Crystallise the quinone from acetic acid or nitrobenzene. It can be sublimed in vacuo. The Cu salt forms red crystals. [Beilstein 8 H 549, 8 I 755, 8 II 584.]

1,2,5,8-TETRAHYDROXYANTHRAQUINONE(81-61-8)Related Product Information

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