5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE Chemical Properties

Boiling point:

600.2±55.0 °C(Predicted)

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

DMSO: ~24 mg/mL, soluble

form 

solid

pka

16.46±0.30(Predicted)

color 

off-white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE Usage And Synthesis

Uses

GR 159897 is an NK2 receptor antagonist which aids in the treatment of IBS.

Biological Activity

A potent, selective, non-peptide, orally active neurokinin NK 2 receptor antagonist. Competes for binding of [ 3 H]GR100679 to hNK 2 -transfected CHO cells with a pK i of 9.5. Inhibits NK 2 receptor-mediated contraction of guinea pig trachea with a pA 2 of 8.7. Anxiolytic in vivo .

storage

Desiccate at -20°C

5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE(158848-32-9)Related Product Information

• 5-FLUORO-N,N-DIMETHYLTRYPTAMINE
• 5-FLUORO-3-[2-[4-METHOXY-4-[[(R)-PHENYLSULPHINYL]METHYL]-1-PIPERIDINYL]ETHYL]-1H-INDOLE