Basic information Safety Supplier Related

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE

Basic information Safety Supplier Related

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Basic information

Product Name:
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
Synonyms:
  • rhamnacene
  • 7,3'-DiMethylquercetin
  • NSC 678106
  • Quercetin 7,3'-DiMethyl Ether
  • RhaMnacine
  • RHAMNAZIN(SH)
  • 3,7-DIMETHYLQUERCETIN
  • 3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
CAS:
552-54-5
MF:
C17H14O7
MW:
330.29
Product Categories:
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
Mol File:
552-54-5.mol
More
Less

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Chemical Properties

Melting point:
214-215 °C
Boiling point:
591.6±50.0 °C(Predicted)
Density 
1.507±0.06 g/cm3(Predicted)
pka
6.14±0.40(Predicted)
form 
powder
BRN 
338203
InChI
InChI=1S/C17H14O7/c1-22-9-6-11(19)14-13(7-9)24-17(16(21)15(14)20)8-3-4-10(18)12(5-8)23-2/h3-7,18-19,21H,1-2H3
InChIKey
MYMGKIQXYXSRIJ-UHFFFAOYSA-N
SMILES
C1(C2=CC=C(O)C(OC)=C2)OC2=CC(OC)=CC(O)=C2C(=O)C=1O
More
Less

Safety Information

WGK Germany 
3
More
Less

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Usage And Synthesis

Uses

Di-O-methylated flavanol; a polyphenolic metabolite of Rhamnus disperma.

Definition

ChEBI: A dimethoxyflavone that is quercetin in which the hydroxy groups at the 3' and 7 positions have been replaced by methoxy groups.

in vivo

Rhamnazin (200 mg/kg; i.g.; daily for 25 days) inhibits breast cancer growth and angiogenesis in mice[1].
Rhamnazin (5-20 mg/kg; i.p.; once) shows strong antioxidant and anti-inflammatory properties in the rat acute lung injury model[2].

Animal Model:BALB/c nude mice, breast cancer xenograft model[1]
Dosage:200 mg/kg
Administration:Intragastric administration, daily for 25 days
Result:Dramatically suppressed tumor volumes by 47% compared with the vehicle group. Showed a significant reduction of pVEGFR2Tyr951-positive cells in tumors. Resulted in downregulation of VEGFR2 downstream molecules phosphorylation including MAPK, AKT and STAT3.

IC 50

VEGFR2: 4.68 μM (IC50)

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONESupplier

J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Email
y.liu@mail.biobiopha.com
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Email
tauto@tautobiotech.com
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Email
526763801@qq.com