5-PHENYLISOXAZOLE-3-CARBOXYLIC ACID Chemical Properties

Melting point:

160-164 °C(lit.)

Boiling point:

434.7±33.0 °C(Predicted)

Density 

1.320

storage temp. 

2-8°C

solubility 

soluble in Methanol

pka

3.33±0.10(Predicted)

form 

Crystalline

color 

White

InChI

InChI=1S/C10H7NO3/c12-10(13)8-6-9(14-11-8)7-4-2-1-3-5-7/h1-6H,(H,12,13)

InChIKey

XJYOBHXWBRKOQO-UHFFFAOYSA-N

SMILES

O1C(C2=CC=CC=C2)=CC(C(O)=O)=N1

CAS DataBase Reference

14441-90-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38-42/43

Safety Statements 

26-36-45

WGK Germany 

2

HazardClass 

IRRITANT

HS Code 

2934999090

MSDS

• Language:English Provider:SigmaAldrich

5-PHENYLISOXAZOLE-3-CARBOXYLIC ACID Usage And Synthesis

Uses

5-Phenylacetic acid is a carboxylic acid derivative that can be used as an intermediate in organic synthesis.

Description

5-Phenylisoxazole-3-carboxylic acid is a phenoxy compound, can be used in pharmaceutical research.

Biological Activity

5-phenylisoxazole-3-carboxylic acid and derivatives have the  ability to inhibit xanthine oxidase (XO).  XO is a key enzyme in the last two steps of purine metabolic pathway, catalyzing the oxidation of hypoxanthine to xanthine, and then to urid acid, which associated with gout and hyperuricemia.

5-PHENYLISOXAZOLE-3-CARBOXYLIC ACID(14441-90-8)Related Product Information

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• ETHYL 5-PHENYL-3-ISOXAZOLECARBOXYLATE
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• METHYL 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXYLATE
• 5-BENZO[1,3]DIOXOL-5-YL-ISOXAZOLE-3-CARBOXYLIC ACID