2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid
2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid Basic information
- Product Name:
- 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid
- Synonyms:
-
- 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid
- KDM5 inhibitor C49
- 159141
- 4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-
- KDM-5-C49,KDM5 C49
- KDM5-C49 hydrochloride
- 2-{[({[2-(dimethylamino)ethyl](ethyl)carbamoyl}methyl)amino]methyl}pyridine-4-carboxylic acid
- 2-(((2-((2-(Dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic
- CAS:
- 1596348-16-1
- MF:
- C15H24N4O3
- MW:
- 308.38
- Mol File:
- 1596348-16-1.mol
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2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid Chemical Properties
- Boiling point:
- 531.0±50.0 °C(Predicted)
- Density
- 1.168±0.06 g/cm3(Predicted)
- pka
- 3.16±0.10(Predicted)
- form
- Solid-Liquid Mixture
- color
- Colorless to light yellow
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2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid Usage And Synthesis
Uses
KDM5-C49 (KDOAM-20) is a potent and selective inhibitor of KDM5 demethylases, with IC50s of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5-C49 can be used for the research of cancer[1].
IC 50
KDM5
References
[1] Horton JR, et, al. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol. 2016 Jul 21;23(7):769-781. DOI:10.1016/j.chembiol.2016.06.006
[2] Song YQ, et al. The role and prospect of lysine-specific demethylases in cancer chemoresistance. Med Res Rev. 2023 Apr 3. DOI:10.1002/med.21955
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