E3 Ligand-Linker Conjugate 6
E3 Ligand-Linker Conjugate 6 Basic information
- Product Name:
- E3 Ligand-Linker Conjugate 6
- Synonyms:
-
- E3 Ligand-Linker Conjugate 6
- Acetamide, N-(3-aminopropyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
- N-(3-aminopropyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
- Pomadomide impurity 26
- CAS:
- 2022182-57-4
- MF:
- C18H20N4O6
- MW:
- 388.37
- Mol File:
- 2022182-57-4.mol
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E3 Ligand-Linker Conjugate 6 Chemical Properties
- Boiling point:
- 755.0±60.0 °C(Predicted)
- Density
- 1.431±0.06 g/cm3(Predicted)
- pka
- 10.68±0.40(Predicted)
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E3 Ligand-Linker Conjugate 6 Usage And Synthesis
Uses
Thalidomide-O-amido-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
IC 50
Cereblon
References
[1] Lohbeck J, et al. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5260-5262. DOI:10.1016/j.bmcl.2016.09.048
E3 Ligand-Linker Conjugate 6Supplier
SuZhou Medinoah Co.,LTD.
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Jilin Province Woda Biotechnology Co., Ltd.
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Molcoo Chemicals Inc.
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Shenzhen Roark Pharma-Tec Co., Ltd.
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E3 Ligand-Linker Conjugate 6(2022182-57-4)Related Product Information
- N-(2-METHOXYETHYL)UREA
- N-(3,4-DIMETHOXY-PHENYL)-GUANIDINE
- N-(2-TRIFLUOROMETHYL-PHENYL)-GUANIDINE
- INDEX NAME NOT YET ASSIGNED
- N-(3,4-dichlorophenyl)oxirane-2-carboxamide
- N-(1-((2-(1,1-dioxido-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)-6-methylquinazolin-4-yl)amino)-3-hydroxy-2-(hydroxymethyl)propan-2-yl)-2,2,2-trifluoroacetamide
- N-(2-Iodo-phenyl)-guanidine
- Cefazolin SodiuM iMpurity G
- Acetamide, N-(3-aminopropyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, hydrochloride (1:1)