TAPI-0
TAPI-0 Basic information
- Product Name:
- TAPI-0
- Synonyms:
-
- N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
- L-Alaninamide, N-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-
- TAPI-0 >=95% (HPLC)
- TAPI
- CAS:
- 163958-73-4
- MF:
- C24H32N4O5
- MW:
- 456.53
- Mol File:
- 163958-73-4.mol
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TAPI-0 Chemical Properties
- Density
- 1.227±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO
- form
- powder
- pka
- 9.17±0.20(Predicted)
- color
- white to off-white
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TAPI-0 Usage And Synthesis
Uses
TAPI 0 is a metalloprotease inhibitor, which inhibits the obligate intracellular human pathogen Chalmydia trachomitis.
Biochem/physiol Actions
TAPI-0 is a metalloproteinase inhibitor with selectivity for TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM). TAPI-0 also inhibits of collagenase and gelatinase. Although not specific for TACE, TAPI-0 is extensively used to block TACE-mediated TNF-α shedding.
storage
Store at -20°C
TAPI-0Supplier
Sigma-Aldrich
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
Hangzhou Peptidego Biotech Co.,Ltd.
- Tel
- 0571-87213919
- Eric@peptidego.com
Shanghai Hongye Biotechnology Co. Ltd
- Tel
- 400-9205774
- sales@glpbio.cn
BOC Sciences
- Tel
- info@bocsci.com
Energy Chemical
- Tel
- 021-58432009 400-005-6266
- marketing@energy-chemical.com