N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide
N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide Basic information
- Product Name:
- N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide
- Synonyms:
-
- N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide
- N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
- N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-5-((3aS,4R,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
- 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propyl]hexahydro-2-oxo-, (3aS,4S,6aR)-
- Biotin-C3-PEG3-C3-NH2
- Biotin-C1-PEG3-C1-NH2
- Biotinyl-C1-PEG3-C1-NH2
- CAS:
- 183896-00-6
- MF:
- C20H38N4O5S
- MW:
- 446.6
- Mol File:
- 183896-00-6.mol
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N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide Chemical Properties
- Boiling point:
- 715.3±60.0 °C(Predicted)
- Density
- 1.139±0.06 g/cm3(Predicted)
- pka
- 13.90±0.40(Predicted)
- form
- Oil
- color
- Colorless to light yellow
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N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide Usage And Synthesis
Uses
Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
[2] Park S, et al. One-step, aid-mediated method for modification of glass surfaces with N-hydroxysuccinimide esters and its application to the construction of microarrays for studies of biomolecular interactions. Bioconjug Chem. 2010 Jul 21;21(7):1246-53. DOI:10.1021/bc100042j
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