2,3-diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one Chemical Properties

Boiling point:

638.6±65.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

4.46±0.10(Predicted)

InChI

InChI=1S/C27H18N4O/c32-27-22(20-13-14-23-21(16-20)12-7-15-28-23)17-29-26-24(18-8-3-1-4-9-18)25(30-31(26)27)19-10-5-2-6-11-19/h1-17,29H

InChIKey

VJMSOWXHWUORTA-UHFFFAOYSA-N

SMILES

C12=C(C3=CC=CC=C3)C(C3=CC=CC=C3)=NN1C(=O)C(C1=CC=C3C(=C1)C=CC=N3)=CN2

2,3-diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one Usage And Synthesis

Uses

AGI-25696 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-25696 blocks growth of MTAP-deleted tumors in vivo.

References

[1] Agios. Targeting MAT2A in MTAP-deleted Cancers. Presented at the American Association for Cancer Research (AACR) Annual Meeting, April 14-18, 2018, Chicago, IL, USA