SIRT5 inhibitor
SIRT5 inhibitor Basic information
- Product Name:
- SIRT5 inhibitor
- Synonyms:
-
- SIRT5 inhibitor
- SIRT5 inhibitor 1
- 3-(3-((S)-6-(((S)-1-(Cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid
- SIRT-5 inhibitor 1,SIRT5 inhibitor 1
- SIRT5 inhibitor 1, 10 mM in DMSO
- CAS:
- 2166487-21-2
- MF:
- C31H39FN6O6S2
- MW:
- 674.81
- Mol File:
- 2166487-21-2.mol
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SIRT5 inhibitor Chemical Properties
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (185.24 mM)
- form
- Solid
- pka
- 4.34±0.10(Predicted)
- color
- White to off-white
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SIRT5 inhibitor Usage And Synthesis
Uses
SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
References
[1] Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14836-14841. DOI:10.1002/anie.201709050
SIRT5 inhibitorSupplier
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