B I09
B I09 Basic information
- Product Name:
- B I09
- Synonyms:
-
- B I09
- 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one
- 5H-[1]Benzopyrano[3,4-c]pyridin-5-one, 7-(1,3-dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-
- B I09,B I-09
- CAS:
- 1607803-67-7
- MF:
- C16H17NO5
- MW:
- 303.31
- Mol File:
- 1607803-67-7.mol
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B I09 Chemical Properties
- Boiling point:
- 486.5±45.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO:11.75(Max Conc. mg/mL);38.74(Max Conc. mM)
- form
- Solid
- pka
- 8.50±0.20(Predicted)
- color
- Yellow to brown
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B I09 Usage And Synthesis
Uses
B I09, is a novel chromenone-based covalent inhibitors of IIRE-1 RNase. It Inhibits IRE-1/XBP1 pathway, and thus growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.
in vivo
B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 μM in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis and do not cause systemic toxicity[2].
storage
Store at -20°C
B I09Supplier
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai Chaolan Chemical Technology Center
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
Shanghai Han-Xiang Chemical Co., Ltd.
- Tel
- 15971444841
- amber@biochempartner.com
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
- Tel
- 18081075745
- chemflowtech@sina.com
BOC Sciences
- Tel
- info@bocsci.com