B I09 Chemical Properties

Boiling point:

486.5±45.0 °C(Predicted)

Density 

1.44±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO:11.75(Max Conc. mg/mL);38.74(Max Conc. mM)

form 

Solid

pka

8.50±0.20(Predicted)

color 

Yellow to brown

B I09 Usage And Synthesis

Uses

B I09, is a novel chromenone-based covalent inhibitors of IIRE-1 RNase. It Inhibits IRE-1/XBP1 pathway, and thus growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.

storage

Store at -20°C