2,4-Dimethoxypyrimidine Chemical Properties

Melting point:

17°C

Boiling point:

204-205 °C (lit.)

Density 

1.1501 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.502(lit.)

Flash point:

198-200 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Oil

pka

2.69±0.20(Predicted)

color 

Clear Colorless

CAS DataBase Reference

3551-55-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

23-24/25-36/37-26

RIDADR 

NA 1993 / PGIII

WGK Germany 

3

HS Code 

29335990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

2,4-Dimethoxypyrimidine Usage And Synthesis

Chemical Properties

Clear colorless to light brown liquid

Uses

2,4-Dimethoxypyrimidine, is a versatile building block used in synthesis of various chemical compounds, such as derivatives of Cytidine (C998300).

Synthesis

The general procedure for the synthesis of 2,4-dimethoxypyrimidine from 6-chloro-2,4-dimethoxypyrimidine was as follows: 1. 6-Chloro-2,4-dimethoxypyrimidine (0.66 mmol) was dissolved in anhydrous THF (13.2 mL) under argon protection and degassed by drumming argon for a few minutes. 2. Catalyst PdCl2 (dppf) (27.0 mg, 0.033 mmol, 5.0 mol%), TMEDA (0.130 g, 1.12 mmol, 1.7 equiv), and reductant NaBH4 (42.4 mg, 1.12 mmol, 1.7 equiv) were added sequentially. 3. The reaction mixture was stirred at room temperature and under argon atmosphere for an appropriate time. 4. After completion of the reaction, post-treatment was carried out according to standard methods.

References

[1] Journal of Molecular Catalysis A: Chemical, 2014, vol. 393, p. 191 - 209
[2] Journal of Organic Chemistry, 1955, vol. 20, p. 829,833,835

2,4-Dimethoxypyrimidine(3551-55-1)Related Product Information

• 6-sulfanilamido-2,4-dimethoxypyrimidine
• 4-AMINO-2,6-DIMETHOXYPYRIMIDINE
• Sulfadimethoxine sodium salt
• 5-BROMO-2,4-DIMETHOXYPYRIMIDINE,5-BROMO-2,6-DIMETHOXYPYRIMIDINE
• 4-CHLORO-2,6-DIMETHOXYPYRIMIDINE,6-CHLORO-2,4-DIMETHOXYPYRIMIDINE
• 5-IODO-2,4-DIMETHOXYPYRIMIDINE
• 2,4-DIETHOXYPYRIMIDINE
• Benzaldehyde
• 2,4-Dimethoxypyrimidine
• (E)-5-(2-CARBOXYVINYL)-2,4-DIMETHOXYPYRIMIDINE
• 2-METHYL-4,6-DIMETHOXYPYRIMIDINE
• Trifloxysulfuron
• Foramsulfuron
• Mesosulfuron-methyl
• Rimsulfuron
• 2-(CHLOROMETHYL)-4,6-DIMETHOXYPYRIMIDINE
• Pyrazosulfuron
• 4,6-DIMETHOXYPYRIMIDINE