1-BENZYL-4-(N-BOC-AMINO) PIPERIDINE 98 Chemical Properties

Melting point:

122-125 °C(lit.)

Boiling point:

400.9±34.0 °C(Predicted)

Density 

1.07±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

12.35±0.20(Predicted)

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29333990

1-BENZYL-4-(N-BOC-AMINO) PIPERIDINE 98 Usage And Synthesis

Chemical Properties

White powder

Synthesis

General procedure for the synthesis of tert-butyl (1-benzylpiperidin-4-yl)carbamate from 4-amino-1-benzylpiperidine and di-tert-butyl dicarbonate: to an anhydrous solution of 4-amino-1-benzylpiperidine (1 mL, 933 mg, 4.9 mmol) in dichloromethane (20 mL) was added triethylamine (1 mL, 725 mg, 7.2 mmol) and di-tert-butyl dicarbonate ( 1.23 g, 5.6 mmol). The reaction mixture was stirred overnight at room temperature and then diluted with dichloromethane (20 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate (10 mL) and saturated saline (10 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give tert-butyl (1-benzylpiperidin-4-yl)carbamate (1.42 g, quantitative yield) as a white solid.

References

[1] Patent: WO2013/140148, 2013, A1. Location in patent: Page/Page column 65
[2] Journal of Medicinal Chemistry, 1999, vol. 42, # 14, p. 2706 - 2715
[3] Journal of Medicinal Chemistry, 1999, vol. 42, # 24, p. 4981 - 5001
[4] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 24, p. 5345 - 5352
[5] Patent: WO2007/46550, 2007, A1. Location in patent: Page/Page column 117

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