1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE& Chemical Properties

Melting point:

56-60 °C(lit.)

Boiling point:

300.3±25.0 °C(Predicted)

Density 

1.06±0.1 g/cm3(Predicted)

solubility 

Well soluble in most organic solvents.

pka

1.44±0.30(Predicted)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE& Usage And Synthesis

Physical properties

mp 55–56 °C.

Uses

1-[(Trimethylsilyl)methyl]- 1H-benzotriazole is a reagent in the preparation of ketones, carboxylic acids,One-carbon Homologation of Carboxylic Acids,Synthesis of Fused Heterocycles and fused heterocycles.

Uses

New Benzotriazole Reagents

Reactant for:

• Alkylation reactions
• Preparation of inhibitor of p53-MDM2 complex formation

• Used as a one-carbon synthon for one-carbon homologation of carboxylic acids

Preparation

1-[(trimethylsilyl)methyl]-1H-benzotriazole is readily prepared in a reaction of sodium benzotriazolide with chloromethyltrimethylsilane.

1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE&(122296-00-8)Related Product Information

• (Trimethylsilyl)methylamine
• 1-((TRIMETHYLSILYL)METHYL)BENZOTRIAZOLE&