DEPMPO Chemical Properties

Boiling point:

412.4±34.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

storage temp. 

Freezer

solubility 

Soluble in Water or Ethanol.

form 

Colorless to light yellow oil.

pka

1.74±0.40(Predicted)

color 

Pale yellow

Stability:

Hygroscopic Oil, Light Sensitive

DEPMPO Usage And Synthesis

Description

DEPMPO (157230-67-6) is a spin trap capable of detecting oxygen, nitrogen, sulfur and carbon-centered free radicals both in vitro and in vivo. DEPMPO is useful for distinguishing between superoxide-dependent pathways of hydroxyl radical generation, and those that are superoxide independent.

Chemical Properties

DEPMPO is Pale Yellow Oil

Uses

DEPMPO is a spin trap useful as a probe for free radical formation during myocardial ischemia/reperfusion injury. An analogue of DMPO

Uses

DEPMPO is the most efficient spin trap for the in vitro detection of O-, N-, S- and C-centered free radicals both invitro and invivo. It has a longer life-time than DMPO and can distinguish between superoxide-dependent and independent mechanisms that lead to the hydroxyl radical. It is less lipophilic (Kp=0.16) than DIPPMPO.

References

1) Liu et al. (1999), Evaluation of DEPMPO as a spin trapping agent in biological systems; Free Radic. Biol. Med., 26 714 2) Shi et al. (2005), Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species; Arch. Biochem. Biophys., 437 59 3) Culcasi et al. (2012), EPR spin trapping evaluation of ROS production in human fibroblasts exposed to cerium oxide nanoparticles: evidence for NADPH oxidase and mitochondrial stimulation; Chem. Biol. Interact., 199 161 4) Tampieri et al. (2019), Comment on “Water Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos; ACS Sens. E-pub. Ahead of Print [Focus Citation]

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