DEPMPO Chemical Properties

Boiling point:

412.4±34.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

storage temp. 

Freezer

solubility 

Soluble in Water or Ethanol.

form 

Colorless to light yellow oil.

pka

1.74±0.40(Predicted)

color 

Pale yellow

Stability:

Hygroscopic Oil, Light Sensitive

DEPMPO Usage And Synthesis

Description

DEPMPO (157230-67-6) is a spin trap capable of detecting oxygen, nitrogen, sulfur and carbon-centered free radicals both in vitro and in vivo. DEPMPO is useful for distinguishing between superoxide-dependent pathways of hydroxyl radical generation, and those that are superoxide independent.

Chemical Properties

DEPMPO is Pale Yellow Oil

Uses

DEPMPO is a spin trap useful as a probe for free radical formation during myocardial ischemia/reperfusion injury. An analogue of DMPO

Uses

DEPMPO is the most efficient spin trap for the in vitro detection of O-, N-, S- and C-centered free radicals both invitro and invivo. It has a longer life-time than DMPO and can distinguish between superoxide-dependent and independent mechanisms that lead to the hydroxyl radical. It is less lipophilic (Kp=0.16) than DIPPMPO.

References

[1] KE JIAN LIU . Evaluation of DEPMPO as a spin trapping agent in biological systems[J]. Free Radical Biology and Medicine, 1999, 26 5: Pages 714-721. DOI:10.1016/s0891-5849(98)00251-2
[2] HONGLIAN SHI . Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species[J]. Archives of biochemistry and biophysics, 2005, 437 1: Pages 59-68. DOI:10.1016/j.abb.2005.02.028
[3] MARCEL CULCASI . EPR spin trapping evaluation of ROS production in human fibroblasts exposed to cerium oxide nanoparticles: Evidence for NADPH oxidase and mitochondrial stimulation[J]. Chemico-Biological Interactions, 2012, 199 3: Pages 161-176. DOI:10.1016/j.cbi.2012.08.007
[4] FRANCESCO TAMPIERI*. Comment on “Water-Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos”[J]. ACS Sensors, 2019, 4 11: 3080-3083. DOI:10.1021/acssensors.9b01358

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