15(R)-ILOPROST Chemical Properties

solubility 

DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml

15(R)-ILOPROST Usage And Synthesis

Description

Iloprost is a second generation structural analog of prostacyclin (PGI₂) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP receptors with a K_i of 11 nM. 15(R)-Iloprost is the “unnatural” or inverted C-15 epimer of iloprost. This transformation frequently attenuates the biological agonist activity of prostaglandin analogs by several orders of magnitude. There are no literature reports of the biological activity of 15(R)-iloprost.

Uses

15(R)-Iloprost is the unnatural or inverted C-15 epimer of lloprost (HY-A0096)[1].

References

[1] W J van der Giessen, et al. The effect of the stable prostacyclin analogue ZK 36374 on experimental coronary thrombosis in the pig. Thromb Res. 1984 Oct 1;36(1):45-51. DOI:10.1016/0049-3848(84)90375-x

15(R)-ILOPROST(85026-51-3)Related Product Information

• Iloprost
• ILOPROST
• 15(R)-ILOPROST