4-[[(5Z,8Z,11Z,14Z)-1-OXO-5,8,11,14-EICOSATETRAENYL]AMINO]BUTANOIC ACID Chemical Properties

Flash point:

17°(63°F)

storage temp. 

Desiccate at -20°C

solubility 

DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 2 mg/ml

form 

Pale yellow viscous oil.

color 

Colorless to light yellow

Sensitive 

Air Sensitive

Safety Information

HazardClass 

3

4-[[(5Z,8Z,11Z,14Z)-1-OXO-5,8,11,14-EICOSATETRAENYL]AMINO]BUTANOIC ACID Usage And Synthesis

Uses

N-Arachidonoyl-GABA is one member of a new class of lipoamino acids related to anandamide identified in bovine brain. N-Arachidonoyl-GABA displays analgesic activity[1].

Definition

ChEBI: N-arachidonoyl-gamma-aminobutyric acid is an N-acyl-gamma-aminobutyric acid resulting from the formal condensation of the amino group of gamma-aminobutyric acid with the carboxy group of arachidonic acid. It has a role as a mammalian metabolite. It is a fatty amide and a N-acyl-gamma-aminobutyric acid. It is functionally related to an arachidonic acid. It is a conjugate acid of a N-arachidonoyl-gamma-aminobutyrate.

Biological Activity

Arachidonyl amino acid; first isolated from bovine brain. Inhibits pain in vivo .

storage

-20°C (desiccate)

References

[1] Huang SM, et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J Biol Chem. 2001 Nov 16;276(46):42639-44. DOI:10.1074/jbc.M107351200

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