AC-AAVALLPAVLLALLAPYVAD-CHO
AC-AAVALLPAVLLALLAPYVAD-CHO Basic information
- Product Name:
- AC-AAVALLPAVLLALLAPYVAD-CHO
- Synonyms:
-
- AC-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-TYR-VAL-ALA-ASP-CHO
- AC-AAVALLPAVLLALLAPYVAD-ALDEHYDE
- AC-AAVALLPAVLLALLAPYVAD-CHO
- CASPASE-1 INHIBITOR (ALDEHYDE)
- CASPASE-1 INHIBITOR I, CELL-PERMEABLE
- ICE INHIBITOR I, CELL-PERMEABLE
- YVAD-CHO, CELL-PERMEABLE
- CASPASE-1 INHIBITOR I, CELL-PERMEABLE ; AC-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-TYR-VAL-ALA-ASP-CHO
- MF:
- C94H155N19O23
- MW:
- 1919.35
- Product Categories:
-
- Pepetides
- peptides
- Mol File:
- Mol File
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AC-AAVALLPAVLLALLAPYVAD-CHO Chemical Properties
- storage temp.
- -20°C
- solubility
- DMSO: 5mg/mL
- form
- solid
- color
- white
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AC-AAVALLPAVLLALLAPYVAD-CHO Usage And Synthesis
Uses
A cell-permeable inhibitor of caspase-1 (ICE; Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki = 1 nM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
Biological Activity
Cell permeable: yes', 'Primary Target
Caspase-1', 'Product does not compete with ATP.', 'Reversible: yes