3-METHYLQUINOLIN-2-ONE CAS#: 2721-59-7

3-METHYLQUINOLIN-2-ONE Basic information

Product Name:

3-METHYLQUINOLIN-2-ONE

Synonyms:

3-METHYLQUINOLIN-2-ONE
3-Methyl-1,2-dihydroquinoline-2-one
3-Methyl-2(1H)-quinolinone
3-methyl-1H-quinolin-2-one
3-methylcarbostyril
3-Methylquinolin-2(1H)-one
3-Methyl-2-quinolinone
3-methyl-3H-quinolin-2-one

CAS:

2721-59-7

MF:

C10H9NO

MW:

159.18

Mol File:

2721-59-7.mol

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3-METHYLQUINOLIN-2-ONE Chemical Properties

Melting point:: 234-235 °C
Boiling point:: 346.0±35.0 °C(Predicted)
Density: 1.136±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.84±0.70(Predicted)
LogP: 1.850 (est)

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3-METHYLQUINOLIN-2-ONE Usage And Synthesis

Uses

3-Methylcarbostyril (compound 5) is a BRD4 BD1 inhibitor with a pIC50 of 4.4[1].

Definition

ChEBI: 3-Methyl-quinolin-2-ol is a quinolone.

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 3740, 1973 DOI: 10.1021/jo00961a019

IC 50

BRD4 BD1: 4.4 (pIC₅₀)

References

[1] Emmanuel H Demont, et al. Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors. J Med Chem. 2015 Jul 23;58(14):5649-73. DOI:10.1021/acs.jmedchem.5b00772

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