Basic information Safety Supplier Related

AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE

Basic information Safety Supplier Related

AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Basic information

Product Name:
AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
Synonyms:
  • AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
  • AS 101
  • CTK8E8213
  • CTK8E8213;RT-011323
  • RT-011323
  • Interleukin Related
  • RPE,NFκB,AS 101,Caspase,Inhibitor,inhibit,AS-101,diseases,immunomodulatory,Ossirene,autoimmune,malignancies,tellurium,IL-6,IL-8,p65,Interleukin Related,STAT3,phosphorylation
  • AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
CAS:
106566-58-9
MF:
C2H4Cl3O2Te.H4N
MW:
312.049
Mol File:
106566-58-9.mol
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AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Chemical Properties

storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO
form 
solid
color 
White crystalline
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AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Usage And Synthesis

Uses

AS 101 inhibits AKT activity in leukemic cells and has bee shown to favorably affect renal pathologies in various animal models. AS 101 inhibition of the AKT downstream pathway by AS101 has clinical potential in alleviating the progression of diabetic nephropathy.

Biological Activity

Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1 α , IL-2 and TNF- α release.

References

[1] kalechman y, sredni b, weinstein t, et al. production of the novel mesangial autocrine growth factors gdnf and il-10 is regulated by the immunomodulator as101[j]. journal of the american society of nephrology, 2003, 14(3): 620-630.
[2] kalechman y, gafter u, weinstein t, et al. inhibition of interleukin-10 by the immunomodulator as101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis association with dephosphorylation of stat3[j]. journal of biological chemistry, 2004, 279(23): 24724-24732.
[3] sredni b, caspi r r, klein a, et al. a new immunomodulating compound (as-101) with potential therapeutic application[j]. nature, 1987, 330(6144): 173-176.
[4] sredni b, albeck m, tichler t, et al. bone marrow-sparing and prevention of alopecia by as101 in non-small-cell lung cancer patients treated with carboplatin and etoposide[j]. journal of clinical oncology, 1995, 13(9): 2342-2353.
[5] kalechman y, gafter u, gal r, et al. anti-il-10 therapeutic strategy using the immunomodulator as101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention[j]. the journal of immunology, 2002, 169(1): 384-392.

AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Email
cfzhang@aikonchem.com
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Email
isunpharm@qq.com
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Email
product02@bidepharm.com
EMMX Biotechnology LLC
Tel
888-539-0666
Email
info@emmx.com
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AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE(106566-58-9)Related Product Information