1-[[(2-NITROPHENYL)AMINO]CARBONYL]-L-PROLYL-N-METHYL-3-(2-NAPHTHALENYL)-N-(PHENYLMETHYL)-L-ALANINAMIDE Chemical Properties

Boiling point:

892.8±65.0 °C(Predicted)

Density 

1.327±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

Soluble to 100 mM in DMSO and to 100 mM in ethanol

form 

Powder

pka

11.66±0.70(Predicted)

1-[[(2-NITROPHENYL)AMINO]CARBONYL]-L-PROLYL-N-METHYL-3-(2-NAPHTHALENYL)-N-(PHENYLMETHYL)-L-ALANINAMIDE Usage And Synthesis

Uses

SDZ NKT 343 is a potent human NK1 tachykinin receptor antagonist.

Biological Activity

Highly selective human tachykinin NK 1 receptor antagonist (IC 50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK 2 and NK 3 receptors. Potently antagonizes SP-induced Ca 2+ efflux in vitro and inhibits mechanical hyperalgesia in vivo .

storage

Store at +4°C

1-[[(2-NITROPHENYL)AMINO]CARBONYL]-L-PROLYL-N-METHYL-3-(2-NAPHTHALENYL)-N-(PHENYLMETHYL)-L-ALANINAMIDE(180046-99-5)Related Product Information

• PYRROLIDINE-1-CARBOXYLIC ACID AMIDE
• 1-[[(2-NITROPHENYL)AMINO]CARBONYL]-L-PROLYL-N-METHYL-3-(2-NAPHTHALENYL)-N-(PHENYLMETHYL)-L-ALANINAMIDE