3-BENZYL-7-CHLORO-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE Chemical Properties

Boiling point:

454.9±35.0 °C(Predicted)

Density 

1.50±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

0.98±0.30(Predicted)

3-BENZYL-7-CHLORO-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-benzyl-7-chloro-3H-[1,2,3]-triazolo[4,5-d]pyrimidines from 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol: To chloroform (50 mL) containing 3-benzyl-7-hydroxy-3H-[1,2,3]triazolo[4,5-d]pyrimidines (10.56 mmol) suspension, N,N-dimethylformamide (DMF, 2 mL) and thionyl chloride (9 mL) were added sequentially. The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure at a temperature below 35 °C. The crude product was purified by silica gel column chromatography with mixed petroleum ether-ethyl acetate solvent as eluent. The final white solid product 3-benzyl-7-chloro-3H-[1,2,3]-triazolo[4,5-d]pyrimidine (1.14 g, 44% yield) was obtained.

References

[1] Patent: EP1598354, 2005, A1. Location in patent: Page/Page column 88

3-BENZYL-7-CHLORO-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE(21410-06-0)Related Product Information

• 3-(4-BROMO-BENZYL)-7-CHLORO-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE
• 3-BENZYL-7-CHLORO-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE
• 7-CHLORO-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE
• 7-chloro-3-methyl-3H-1,2,3-triazolo(4,5-d)pyrimidine