4-(5-HYDROXYMETHYLIMIDAZOL-1-YLMETHYL)BENZONITRILE Chemical Properties

form 

Solid

color 

White to off-white

4-(5-HYDROXYMETHYLIMIDAZOL-1-YLMETHYL)BENZONITRILE Usage And Synthesis

Uses

CYP19A1/CYP11B2-IN-1 (Compound X21) is a potent and selective aromatase and aldosterone synthase dual inhibitor with IC50s of 2.3 nM and 29 nM for aromatase (CYP19A1) and aldosterone synthase (CYP11B2), respectively. CYP19A1/CYP11B2-IN-1 has excellent antiproliferative and pro-apoptotic activity against the cancer cell. CYP19A1/CYP11B2-IN-1 can be used for research of breast cancer[1].

References

[1] Tinivella A, et al. Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase. ACS Pharmacology & Translational Science. 2023 Nov 23. DOI:10.1021/acsptsci.3c00183

4-(5-HYDROXYMETHYLIMIDAZOL-1-YLMETHYL)BENZONITRILE(183500-36-9)Related Product Information

• 4-(5-HYDROXYMETHYLIMIDAZOL-1-YLMETHYL)BENZONITRILE
• 4-(1H-IMIDAZOL-1-YLMETHYL)BENZONITRILE