Setiptiline Chemical Properties

Melting point:

>120°C (dec.)

Boiling point:

421.7±34.0 °C(Predicted)

Density 

1.15

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

8.34±0.20(Predicted)

color 

White to Light Yellow

Setiptiline Usage And Synthesis

Description

Setiptiline is a mianserin analog reportedly useful in the treatment of depression with a favorable side-effect profile. It is a potent antagonist of alpha-receptors, with greater affinity at alpha, than alpha, sites, as well as an inhibitor of central serotonin receptors.

Originator

Organon (Netherlands)

Uses

Setiptiline is a tetracyclic antidepressant. Setiptiline acts as a noradrenergic and specific serotonergic antidepressant (NaSSA).

Definition

ChEBI: Setiptiline is a tetracyclic antidepressant that is 2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine carrying a methyl group at position 2. Its maleate salt is used for the treatment of depression in Japan. It has a role as an alpha-adrenergic antagonist and a serotonergic antagonist. It is a tetracyclic antidepressant and a tertiary amino compound. It is a conjugate base of a setiptiline(1+).

brand name

Tecipul

Setiptiline(57262-94-9)Related Product Information

• Teprenone
• Cycloheptatriene
• Setiptiline maleate
• 1,2,3,6-Tetrahydro-4-phenyl-pyridine
• 5H-dibenzo[a,d]cycloheptene
• Setiptiline
• 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
• Dimethyl-(3-phenyl-but-3-enyl)-amine