Basic information Safety Supplier Related

tibric acid

Basic information Safety Supplier Related

tibric acid Basic information

Product Name:
tibric acid
Synonyms:
  • tibric acid
  • Tibric
  • 2-Chloro-5-[(3α,5α-dimethylpiperidino)sulfonyl]benzoic acid
  • 2-Chloro-5-[[(3R,5S)-3,5-dimethylpiperidino]sulfonyl]benzoic acid
  • 2-Chloro-5-[[(3S,5R)-3,5-dimethylpiperidino]sulfonyl]benzoic acid
  • CP-18524
CAS:
37087-94-8
MF:
C14H18ClNO4S
MW:
331.818
EINECS:
2533440
Mol File:
37087-94-8.mol
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tibric acid Chemical Properties

form 
Solid
color 
White to off-white
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tibric acid Usage And Synthesis

Uses

Tibric acid (CP 18524) has similar effects to those of hypolipidemic agents. Tibric acid has orally active triglyceride-lowering effects. Tibric acid can be used for research of hypertriglyceridemia[1][2].

in vivo

Tibric acid (13-125 mg/kg/d, oral administration, daily for 1 week) reduces serum cholesterol and triglyceride levels in rats[2].

Animal Model:Rats[1]
Dosage:13, 25, 125 mg/kg/d
Administration:oral administration, daily for 1 week
Result:Decreased serum cholesterol and triglyceride levels, but increased total liver content of cholesterol, phospholipids, and triglycerides.

References

[1] Bielmann P, et al. Dose-response to tibric acid: a new hypolipidemic drug in type IV hyperlipoproteinemia. Clin Pharmacol Ther. 1975 May;17(5):606-11. DOI:10.1002/cpt1975175606
[2] Cayen MN, et al. Effect of tibric acid on hepatic cholesterol synthesis in rats. Lipids. 1977 Aug;12(8):684-8. DOI:10.1007/BF02533766

tibric acidSupplier

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tibric acid(37087-94-8)Related Product Information