3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate
3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate Basic information
- Product Name:
- 3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate
- Synonyms:
-
- 3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate
- Pregnane-11,20-dione, 21-(acetyloxy)-3-hydroxy-, (3.alpha.,5.alpha.)-
- 21-(Acetyloxy)-3α-hydroxy-5α-pregnane-11,20-dione
- 21-Acetoxy-3α-hydroxy-5α-pregnane-11,20-dione
- Alphadolone acetate
- GR-2/1574
- (3-alpha,5-alpha)-21-(Acetyloxy)-3-hydroxypregnane-11,20-dione
- 21-Acetoxy-3-alpha-hydroxy-5-alpha-pregnane-11,20-dione
- CAS:
- 23930-37-2
- MF:
- C23H34O5
- MW:
- 390.51306
- EINECS:
- 2459425
- Mol File:
- 23930-37-2.mol
3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate Chemical Properties
- Melting point:
- 175-177°
- alpha
- D26 +97° (c = 1.02 in chloroform)
- Boiling point:
- 523.6±50.0 °C(Predicted)
- Density
- 1.164±0.06 g/cm3(Predicted)
- pka
- 15.04±0.70(Predicted)
- form
- Solid
- color
- White to off-white
3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate Usage And Synthesis
Uses
Alphadolone acetate (Alfadolone acetate) is a steroid agent that can suppress or relieve pain, with antinociception[1].
Definition
ChEBI: Acetic acid [2-[(3R,5S,8S,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-11-oxo-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester is a corticosteroid hormone.
in vivo
Alphadolone acetate (anaesthetized with a 3:1 mixture of Alphaxalone and Alphadolone acetate; i.m.) blocks the oestrogen-stimulated luteinizing hormone (LH) surge and impairs pulsatile secretion in female rats, when combined with alphaxalonet[2].
Alphadolone acetate (14 mL/kg; i.p.; single dosage) decreases serum concentrations of LH in castrated rats[3].
| Animal Model: | Inbred Wistar-derived colony female rats (intramuscularly injected with 20 μg/100g oestradiol benzoate)[2] |
| Dosage: | Anaesthetized with a 3 :1 mixture of Alphaxalone and Alphadolone acetate |
| Administration: | i.m. |
| Result: | Blocked the oestrogen-stimulated LH surge and impairs pulsatile secretion. |
| Animal Model: | Male Sprague-Dawley rats (orchidectomized; aged 90-120 days and weighing 300-350 g)[3] |
| Dosage: | 14 mL/kg |
| Administration: | i.p.; single dosage |
| Result: | Decreased serum concentrations of LH. |
References
[1] Nadeson R, et al. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors. Pain. 2000 Oct;88(1):31-39. DOI:10.1016/S0304-3959(00)00300-6
[2] Dyer RG, Mansfield S. Anaesthesia with alphaxalone plus alphadolone acetate blocks the oestrogen-stimulated LH surge and impairs pulsatile LH secretion in ovariectomized female rats. J Endocrinol. 1984 Jul;102(1):27-31. DOI:10.1677/joe.0.1020027
[3] Emanuele MA, et al. Anaesthesia with alphaxalone plus alphadolone acetate decreases serum concentrations of LH in castrated rats. J Endocrinol. 1987 Nov;115(2):221-3. DOI:10.1677/joe.0.1150221
3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetateSupplier
- Tel
- 025-57798810
- sales@sunlidabio.com
- Tel
- 0755-85201366 18938635012
- sales@regentsciences.com
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Tel
- +86-0571-85134551
- sales@afinechem.com
- Tel
- 13574065797
- 2675013845@qq.com