7-(diethylamino)-3-(5-methylbenzoxazol-2-yl)-2-benzopyrone
7-(diethylamino)-3-(5-methylbenzoxazol-2-yl)-2-benzopyrone Basic information
- Product Name:
- 7-(diethylamino)-3-(5-methylbenzoxazol-2-yl)-2-benzopyrone
- Synonyms:
-
- 7-(diethylamino)-3-(5-methylbenzoxazol-2-yl)-2-benzopyrone
- 3-(5-Methylbenzoxazole-2-yl)-7-(diethylamino)-2H-1-benzopyran-2-one
- 3-(5-Methylbenzoxazole-2-yl)-7-(diethylamino)coumarin
- 7-Diethylamino-3-(5-methylbenzoxazol-2-yl)-2H-1-benzopyran-2-one
- EMI48
- 2H-1-Benzopyran-2-one, 7-(diethylamino)-3-(5-methyl-2-benzoxazolyl)-
- CAS:
- 34564-13-1
- MF:
- C21H20N2O3
- MW:
- 348.4
- EINECS:
- 252-093-4
- Mol File:
- 34564-13-1.mol
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7-(diethylamino)-3-(5-methylbenzoxazol-2-yl)-2-benzopyrone Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: 9.26 mg/mL (26.58 mM)
- form
- Solid
- color
- Light yellow to yellow
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7-(diethylamino)-3-(5-methylbenzoxazol-2-yl)-2-benzopyrone Usage And Synthesis
Uses
EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1].
IC 50
EGFRL858R/T790M/C797S; EGFRdel19 T790M C797S
storage
Store at -20°C
References
[1] Punit Saraon , et al. A Drug Discovery Platform to Identify Compounds That Inhibit EGFR Triple Mutants.Nat Chem Biol. 2020 May;16(5):577-586. DOI:10.1038/s41589-020-0484-2
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