tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride
tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride Basic information
- Product Name:
- tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride
- Synonyms:
-
- tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride
- 1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride
- 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride
- Adobiol
- bufetolol hydrochloride
- Bufetolol-hydrochloride
- DL-1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride
- Y 6124
- CAS:
- 35108-88-4
- MF:
- C18H30ClNO4
- MW:
- 359.8881
- EINECS:
- 252-369-4
- Mol File:
- 35108-88-4.mol
tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride Chemical Properties
- Melting point:
- 153.5-157°; mp 151-154°; (Diastereoisomer, mp 118°)
tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride Usage And Synthesis
Originator
Bufetolol,ZYF Pharm
Definition
ChEBI: Bufetolol hydrochloride is an aromatic ether.
Manufacturing Process
To a solution of 1 gramm equivalent (g-eq.) of 1-bromo-3-[2- (tetrahydrofuran-2-yloxy)phenoxy]propan-2-ol in 30 ml of ethanol is added 1 g-eq. of t-butylamine, the mixture is refluxed for 6 hours, and then the ethanol is distilled off. The residue is dissolved in benzene and the solution is extracted twice with 5% oxalic acid. The aqueous extract is made alkaline with potassium hydroxide and the isolated oil is extracted with benzene. The benzene extract is dried over potassium carbonate and the benzene is distilled off to give of oily 1-(t-butylamino)-3-(o-((tetrahydrofurfuryl)oxy)phenoxy)-2- propanol. The corresponding acid fumarate melts at 128°-132°C.
Therapeutic Function
Antiarrhythmic, Beta-adrenergic blocker