5-Methoxy-2-fluorobenzyl cyanide Chemical Properties

Boiling point:

279℃

Density 

1.148

Flash point:

122℃

storage temp. 

Sealed in dry,Room Temperature

form 

crystalline powder

color 

White

Safety Information

HS Code 

2909309090

5-Methoxy-2-fluorobenzyl cyanide Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-fluoro-5-methoxyphenylacetonitrile from the compound (CAS: 773837-37-9) and 2-fluoro-5-methoxybenzyl bromide: Sodium cyanide (362 mg, 7.53 mmol) was added to a solution of compound 4 (1.5 g, 6.84 mmol) in anhydrous ethanol (15 mL), and the reaction mixture was stirred for 2 hr at 85 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of the raw materials, the reaction mixture was concentrated to obtain the crude product. The crude product was diluted with ice water (30 mL) and extracted with ethyl acetate (2 x 50 mL). The organic layers were combined, washed with brine (20 mL), dried over anhydrous sodium sulfate and concentrated to give the residue. The residue was purified by rapid chromatography on silica gel (eluent: petroleum ether/ethyl acetate, gradient gradually increased from 100/0 to 70/30) to afford compound 5 (1 g, 90% yield) as a colorless liquid.1H NMR (400 MHz, DMSO-d6) δ: 7.21 (t, J = 9.2 Hz, 1H), 7.01 (dd, J = 6.1, 3.1 Hz, 1H), 6.94 (m, 1H), 4.01 (s, 2H), 3.75 (s, 3H). Mass spectrum (ESI) m/z: 166.06 [M+H]+.

References

[1] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 302-303

5-Methoxy-2-fluorobenzyl cyanide(672931-28-1)Related Product Information

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