BAY U6751 HYDRATE
BAY U6751 HYDRATE Basic information
- Product Name:
- BAY U6751 HYDRATE
- Synonyms:
-
- 4-(2-Chlorophenyl)-1-ethyl-1,4-dihydro-6-methyl-2,3,5-pyridinetricarboxylic acid 5-isopropyl ester disodium salt hydrate
- BAY U6751
- CAS:
- 114290-51-6
- MF:
- C20H20ClNNa2O6
- MW:
- 451.80844
- Mol File:
- 114290-51-6.mol
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BAY U6751 HYDRATE Chemical Properties
- storage temp.
- 2-8°C
- solubility
- H2O: >8mg/mL
- form
- solid
- color
- white
- Water Solubility
- H2O: >8mg/mL
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BAY U6751 HYDRATE Usage And Synthesis
Biochem/physiol Actions
BAY W1807, the active metabolite of BAY R3401, inhibits muscle glycogen phosphorylase a and b. In gel-filtered liver extracts, racemic BAY U6751 (containing active BAY W1807) was tested for inhibition of phosphorylase in the glycogenolytic (in which only phosphorylase a is active). In liver extracts, BAY U6751 (0.9-36 μmol/L) inhibited glycogen synthesis by phosphorylase b (notwithstanding the inclusion of AMP), but not by phosphorylase a. Inhibition of phosphorylase-a-catalyzed glycogenolysis was partially relieved by AMP (500 μmol/L). BAY U6751 facilitated phosphorylase-a dephosphorylation. Isolated hepatocytes and perfused livers were tested for BAY R3401-induced changes in phosphorylase-a:b ratios and glycogenolytic output.