NEOTROFIN
NEOTROFIN Basic information
- Product Name:
- NEOTROFIN
- Synonyms:
-
- 4-{[3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanoyl]amino}benzoic acid
- NEOTROFIN
- 4-[[3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic Acid Potassium Salt
- Leteprinim Potassium Salt
- Potassium,4-[3-(6-oxo-3H-purin-9-yl)propanoylamino]benzoate
- Leteprinim potassium
- SPI 205
- SPI205
- CAS:
- 192564-13-9
- MF:
- C15H12N5O4.K
- MW:
- 365.389
- Product Categories:
-
- Heterocycles, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
- Bases & Related Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- Mol File:
- 192564-13-9.mol
More
Less
NEOTROFIN Chemical Properties
- Melting point:
- 268-270°C (dec.)
- storage temp.
- Refrigerator
- solubility
- Water
- form
- Solid
- color
- Off White to Pale Yellow
More
Less
NEOTROFIN Usage And Synthesis
Chemical Properties
Off White to Pale Yellow Solid
Uses
A synthetic purine derivative with neuroprotective effects. A cognitive enhancer, is transported into brain by a nonsaturable influx mechanism and out of brain by a saturable efflux mechanism.
brand name
Neotrofin (NeoTherapeutics).
in vivo
Leteprinim (30 or 60 mg/kg, i.p., for 7 days) potassium protect rats against Kainate (12 mg/kg) induced excitotoxicity of hippocampal neurons[1].
Leteprinim (60 mg/kg, i.p.) potassium enhances working memory in young and aged mice[3].
Leteprinim (60 mg/kg; i.p.; single dosage) potassium significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[4].
| Animal Model: | Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)[4] |
| Dosage: | 60 mg/kg |
| Administration: | IP; single dosage |
| Result: | The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group. In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline. |
NEOTROFINSupplier
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
Chemsky（shanghai）International Co.,Ltd.
- Tel
- 021-50135380
- shchemsky@sina.com
Spectrum Chemical Manufacturing Corp.
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- marketing_china@spectrumchemical.com
Shanghai TaoSu Biochemical Technology Co., Ltd.
- Tel
- 021-33632979
- info@tsbiochem.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com