leminoprazole
leminoprazole Basic information
- Product Name:
- leminoprazole
- Synonyms:
-
- 2-[[2-(Methylisobutylamino)benzyl]sulfinyl]-1H-benzimidazole
- NC-1300-O-3
- NC-1300O-3
- N-Methyl-N-(2-methylpropyl)-2-[[(1H-benzimidazol-2-yl)sulfinyl]methyl]benzenamine
- CAS:
- 104340-86-5
- MF:
- C19H23N3OS
- MW:
- 341.47
- Mol File:
- 104340-86-5.mol
leminoprazole Chemical Properties
- Boiling point:
- 567.4±60.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- pka
- 9.76±0.10(Predicted)
leminoprazole Usage And Synthesis
Uses
Leminoprazole (NC 1300O3) is an inhibitor for acid pump, H+ K+-ATPase,. Leminoprazole stimulates the secretion and synthesis of gastric mucus, attenuates gastric ulcers. Leminoprazole is orally active[1][2][3].
in vivo
Leminoprazole (10-90 mg/kg, po, single dose) promotes the synthesis of gastric mucus, inhibits gastric acid secretion in Donryu rats model[3].
| Animal Model: | Donyru rats model[3] |
| Dosage: | 10-90 mg/kg |
| Administration: | p.o., single dose |
| Result: | Increased levels of glucosamine, decreased acid secretion. |
References
[1] Masuda M, et al., [Studies on the inhibitory action of leminoprazole against rabbit gastric H+,K(+)-ATPase]. Nihon Yakurigaku Zasshi. 1994 Oct;104(4):325-35. Japanese. DOI:10.1254/fpj.104.325
[2] Saito E, et al., Inhibitory effect of leminoprazole on acid secretion in parietal cells isolated from guinea pig gastric mucosa. Jpn J Pharmacol. 1995 May;68(1):19-23. DOI:10.1254/jjp.68.19
[3] Takahashi S, et al., Mechanism by which orally administered leminoprazole stimulates mucus synthesis in rats. Pharmacology. 1998 Jul;57(1):47-56. DOI:10.1159/000028225
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