Cycloguanil Chemical Properties

Melting point:

146°

Boiling point:

397.13°C (rough estimate)

Density 

1.2332 (rough estimate)

refractive index 

1.6110 (estimate)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

color 

White to off-white

Cycloguanil Usage And Synthesis

Uses

Antimalarial.

Definition

ChEBI: Cycloguanil is a triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antiinfective agent, an antiparasitic agent, an antimalarial, an antiprotozoal drug and an antifolate.

Cycloguanil(516-21-2)Related Product Information

• 1,3,5-Triazaspiro(5.5)undeca-2,4-diene, 1-(4-chlorophenyl)-2,4-diamino -8-methyl-, hydrochloride
• Cycloguanil