Metioprim
Metioprim Basic information
- Product Name:
- Metioprim
- Synonyms:
-
- Metioprim
- Ro 12-6995
- 2,4-Diamino-5-[3,5-dimethoxy-4-methylthiobenzyl]pyrimidine
- 5-[[3,5-Dimethoxy-4-(methylthio)phenyl]methyl]-2,4-pyrimidinediamine
- 2,4-Pyrimidinediamine, 5-[[3,5-dimethoxy-4-(methylthio)phenyl]methyl]-
- He 909
- He909
- Aditoprim impurity 1
- CAS:
- 68902-57-8
- MF:
- C14H18N4O2S
- MW:
- 306.38
- Mol File:
- 68902-57-8.mol
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Metioprim Chemical Properties
- Boiling point:
- 563.3±60.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- pka
- 7.04±0.10(Predicted)
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Metioprim Usage And Synthesis
Uses
Antibacterial.
in vivo
Metioprim (5 mg/kg or 10 mg/kg; i.v.; single dose) has a shorter elimination half-life in goat than in pig (23 min vs 169 min), and its main metabolites are methionine sulfoxide and methoxysulfonic acid[3].
Pharmacokinetic Analysis[1]
| Animal | Route | Dose (mg/kg) | C0 (μg/mL) | A (μg/mL) | α (1/min) | t1/2α (min) | B (μg/mL) | β (1/min) | t1/2β (min) | VC (1/kg) | Vp (1/kg) | Vd,ss (1/kg) | Clβ (mL/min/kg) |
| Pigs | i.v. | 5 | 3.6 | 2.1 | 0.032 | 25 | 1.5 | 0.00415 | 169 | 1.45 | 0.74 | 2.19 | 10.0 |
| Goats | i.v. | 10 | 12.2 | 6.4 | 0.220 | 4 | 5.6 | 0.03138 | 23 | 0.85 | 0.44 | 1.28 | 49 |