ABT-594 Chemical Properties

Melting point:

116-117 °C

Boiling point:

321.1±22.0 °C(Predicted)

Density 

1.228±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

H₂O: 2 mg/mL, clear

pka

10.05±0.40(Predicted)

form 

powder

color 

white to beige

Water Solubility 

H2O: 2mg/mL, clear

InChI

1S/C9H11ClN2O/c10-9-2-1-8(5-12-9)13-6-7-3-4-11-7/h1-2,5,7,11H,3-4,6H2/t7-/m1/s1

InChIKey

MKTAGSRKQIGEBH-SSDOTTSWSA-N

SMILES

Clc1ncc(cc1)OC[C@@H]2NCC2

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Hazard Classifications

STOT SE 3

Toxicity

mouse,LD50,intraperitoneal,3794ug/kg (3.794mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,European Journal of Pharmacology. Vol. 346, Pg. 23, 1998.

ABT-594 Usage And Synthesis

Uses

Analgesic (cholinergic channel modulator).

Biological Activity

Tebanicline (ABT-594) is a partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. It is a less toxic analog of epibatidine with potent antinociceptive effects.

ABT-594(198283-73-7)Related Product Information

• ABT-594
• 2-Chloro-5-hydroxypyridine
• 2-CHLORO-5-METHOXYPYRIDINE
• (R)-2-AZETIDINEMETHANOL